Browsing by Author "Tas, Ayca"
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The effects of colostrum on some biochemical parameters in the experimental intoxication of rats with paracetamol
Karabacak, Mursel; Kanbur, Murat; Eraslan, Gokhan; Silig, Yavuz; Sarica, Zeynep Soyer; Tekeli, Muhammet Yasin; Tas, Ayca (SPRINGER HEIDELBERG, 2018)In the current study, the possible prophylactic and therapeutic effects of colostrum (COL) on acute organ injury caused by paracetamol (PAR) in rats were evaluated. Within the scope of this study, a 2-month-old male (150-200 ... -
An in vitro Study of Cytotoxic Activity of Euphorbia macroclada boiss on Mcf-7 Cells
Tas, Ayca; Sahin-Bolukbasi, Serap; Cevik, Esranur; Ozmen, Esma; Gumus, Erkan; Silig, Yavuz (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2018)Objective: The study was aimed to evaluate the cytotoxic activity of acetone extract of leaves, flower and body of Euphorbia macroclada boiss on human breast cancer cell line (MCF-7). Material: The cells were plated at a ... -
Investigation of the association between the MDM2 T309G polymorphism and gastric cancer
Tas, Ayca; Atabey, Mustafa; Caglayan, Gulcin; Bostanci, Meric Emre; Bolukbasi, Serap Sahin; Topcu, Omer; Silig, Yavuz (SPANDIDOS PUBL LTD, 2017)Murine double minute clone 2 oncoprotein (MDM2) is a key component in the regulation of the tumour suppressor p53. The association between the MDM2 polymorphism and gastric cancer (GC) has been investigated in Turkish ... -
Is there a relation between Murine double minute 2 T309G polymorphism and lung cancer risk in the Turkish population?
Yilmaz, Meral; Tas, Ayca; Kacan, Turgut; Sari, Musa; Silig, Yavuz (WALTER DE GRUYTER GMBH, 2017)Introduction: Association between Murine double minute 2 T309G polymorphism and lung cancer risk has been investigated in several populations, but results of these studies are inconsistent. We aimed to investigate the ... -
Manganese-superoxide dismutase (MnSOD) polymorphisms
Silig, Yavuz; Tas, Ayca; Pinarbasi, Hatice (WALTER DE GRUYTER GMBH, 2015)Objective: Manganese superoxide dismutase (MnSOD, SOD2), the only known superoxide scavenger in mitochondria, may be particularly important for antioxidant defense because mitochondria are the major sites for cellular ... -
Role of SOD2 Ala16Val polymorphism in primary brain tumors
Tas, Ayca; Silig, Yavuz; Pinarbasi, Hatice; Gurelik, Mustafa (SPANDIDOS PUBL LTD, 2019)The present study aimed to investigate the possible association between the genetic polymorphism of the enzyme superoxide dismutase 2 (SOD2, also known as manganese-dependent SOD), Ala16Val (rs4880), and primary brain tumor ... -
Significant association between MDM2 T309G polymorphism and colorectal cancer
Atabey, Mustafa; Tas, Ayca; Sari, Ismail; Bostanci, Meric Emre; Topcu, Omer; Silig, Yavuz (IMPRIMATUR PUBLICATIONS, 2019)Purpose: The Murine double minute 2 (MDM2) gene plays a crucial role in regulating and suppressing the function of apoptotic pathway. We investigated the relationship between MDM2 gene SNP309 (T309G) (rs2279744) polymorphism ... -
Superoxide Dismutase 1 (SOD 1) A251G Polymorphism
Silig, Yavuz; Tas, Ayca; Sahin-Bolukbasi, Serap; Caglayan, Gulcin; Sari, Ismail (WALTER DE GRUYTER GMBH, 2017)Objective: A genetic polymorphism of SOD1 A251G(rs2070424) is in the 3rd intron region of the SOD gene. The aim of this study was to determine the frequencies of the polymorphisms of the SOD1 A251G in a Turkish population, ...